The 2025 NFL Playoffs continue this week with the NFL Divisional Round, featuring four exciting games on the schedule. In the NFC, we have the Lions taking on the Commanders on Saturday, followed by the Eagles facing the Rams on Sunday. Over in the AFC, Saturday's matchup will see the Chiefs square off against the Texans, while Sunday brings the Bills against the Ravens. The current odds for the 2025 Divisional Round list the Chiefs as eight-and-a-half point favorites (41. 5) and the Lions as nine-and-a-half point favorites (55. 5) for Saturday. On Sunday, the Ravens are favored by one point (51. 5) and the Eagles by six points (43. 5). Notably, Texans star running back Joe Mixon is questionable due to an ankle injury, and Ravens receiver Zay Flowers is doubtful with a knee issue. As the Divisional Round unfolds, you might be wondering who will prevail in these matchups and how to approach your NFL picks regarding the spread, over-under, and moneyline. Before making any selections or scores predictions for the playoffs, it’s essential to check the predictions for the spread, over-under, and moneyline, all powered by the advanced SportsLine AI. Developed by SportsLine's Data Science team using state-of-the-art artificial intelligence and machine learning methods, the AI Predictions and Ratings are produced for each matchup. These predictions rely on a thorough analysis of each team's historical performance and a quantitative assessment of their opponents' defenses, represented by a numerical value out of 100 known as a matchup score. Once a prediction is established, the AI rating is determined using the prediction, the matchup score, and the prevailing odds in the market. For instance, if a team with a strong offense faces a weak defense, a high rating may be given to an over bet, especially if the prediction diverges from the line and the odds are appealing. Furthermore, SportsLine AI stands as the first fully automated predictive model available at SportsLine. It constantly updates with the latest data, helping users identify significant discrepancies in the betting lines.

Notably, the SportsLine AI PickBot has achieved an impressive record, hitting 1, 390 prop picks rated 4. 5 stars or higher since the beginning of last season with a 48% accuracy rate. Additionally, bets on the under have historically hit at a 54. 5% rate. The bot also excelled during the 2025 NFL Wild Card Weekend, successfully selecting six out of seven A+ picks. As for Divisional Round betting insights, the AI PickBot has assessed the odds and generated picks for all four matchups. You can access the AI predictions for the 2025 NFL Divisional Round exclusively here. Key NFL Divisional Round AI selections After analyzing each game of the 2025 NFL Divisional Round, the AI PickBot confidently predicts the Bills will cover as one-point home underdogs against the Ravens on Sunday (O/U 51. 5). Earlier this season, these AFC East and AFC North champions faced off in Baltimore, with Lamar Jackson’s team dominating in a 35-10 win. However, the rematch will take place in Buffalo, where the Bills previously held the advantage during their last postseason encounter in western New York. Josh Allen led his team to a 17-3 victory as 2. 5-point favorites during the 2021 NFL Divisional Round in harsh weather conditions. Coming off a powerful win against the Broncos, Allen completed 20 of 26 passes for 272 yards, two touchdowns, and added 46 rushing yards in a 31-7 victory as 8. 5-point home favorites. With snow showers expected throughout the week, the conditions favor Buffalo, providing Allen with another chance to make a statement in a key matchup against Jackson, a two-time NFL MVP. The AI PickBot rates the Bills covering as an A+ pick and anticipates a score of 32-22 in their favor. Discover the AI’s other predictions and picks for the NFL Divisional Round at SportsLine. How to execute your NFL Divisional Round predictions The AI PickBot has produced four highly sought-after A+ picks for the 2025 NFL Divisional Round, including another underdog predicted to win outright for a substantial return. Be sure to check the AI PickBot's NFL picks before finalizing any of your own NFL Divisional Round bets, exclusively available at SportsLine.