The 2025 NFL Playoffs are in full swing this week with the NFL Divisional Round, featuring four exciting matchups on the schedule. In the NFC, the Lions will face off against the Commanders on Saturday, while on Sunday, the Eagles will take on the Rams. In the AFC, Saturday brings the Chiefs battling the Texans, followed by the Bills squaring off against the Ravens on Sunday. The latest odds for the 2025 Divisional Round show the Chiefs as 8. 5-point favorites with an over/under of 41. 5, while the Lions are favorites at 9. 5 with an over/under of 55. 5. On Sunday, the Ravens are slight favorites at -1 with a total of 51. 5, and the Eagles are favored at -6 with an over/under of 43. 5. Joe Mixon, the Texans' standout running back, is questionable due to an ankle injury but is expected to play, whereas Ravens receiver Zay Flowers is doubtful due to a knee issue. Who will emerge victorious in all four Divisional Round games, and how should you approach your NFL picks against the spread, over-under bets, and moneyline wagers?Before making any predictions regarding the Divisional Round, be sure to consult the NFL predictions powered by the advanced SportsLine AI. Developed by SportsLine's Data Science team using state-of-the-art artificial intelligence and machine learning techniques, the AI generates predictions and ratings for each game. These predictions are based on a statistical analysis of each team’s historical performance, as well as a quantitative assessment of each opponent’s defensive strength, represented by a matchup score on a scale of 100. Once a prediction is made, the AI rating is calculated based on the prediction, the matchup score, and the prevailing market odds. For instance, you might encounter an A rating for an over bet if a team is up against a weak defense, their prediction is at odds with the spread, and the odds are favorable. Moreover, SportsLine AI is the first fully automated predictive model from SportsLine, continuously updating with the latest available data to highlight significant line discrepancies.

The SportsLine AI PickBot has achieved an impressive 1, 390 successful NFL prop picks rated 4. 5 and 5 stars since the previous season with a 48% accuracy rate. Overall, under bets have a hit rate of 54. 5%, and it successfully nailed six out of seven A+ picks during the NFL Wild Card Weekend of 2025. For NFL betting during the divisional round, the AI PickBot has analyzed the odds and provided picks for all four games. You can access the 2025 NFL Divisional Round AI predictions exclusively here. Top NFL Divisional Round AI Picks After evaluating all matchups in the 2025 NFL Divisional Round, the AI PickBot predicts that the Bills will comfortably cover as one-point home underdogs against the Ravens (O/U 51. 5) on Sunday. Earlier this season, the AFC East and AFC North champions faced off in Baltimore, with Lamar Jackson's team dominating in a 35-10 victory. However, this rematch will occur in Buffalo, where the Bills triumphed in their last postseason clash against the Ravens in Western New York. During the 2021 NFL Divisional Round, Josh Allen led his team to a 17-3 victory as 2. 5-point favorites in frigid conditions, and he is coming off another impressive performance against the Broncos, where he completed 20 of 26 passes for 272 yards and two touchdowns, along with 46 rushing yards in a 31-7 win as 8. 5-point favorites. With snow showers expected throughout the week, Buffalo may benefit from the weather, giving Allen another opportunity for a pivotal moment in a high-profile matchup against Jackson, a two-time NFL MVP. The AI PickBot assigns an A+ rating to the Bills covering the spread and forecasts a 32-22 victory. Check out the AI's additional NFL Divisional Round score predictions and football picks at SportsLine. How to Make NFL Divisional Round Predictions The AI PickBot has produced a total of four sought-after A+ picks for the 2025 NFL Divisional Round, including another underdog expected to win outright for a substantial payout. Be sure to review the AI PickBot's NFL picks before placing your own bets on the NFL Divisional Round. They are available exclusively at SportsLine.