The final week of the regular NFL season is here, with Week 18 featuring a crucial clash between the Detroit Lions and Minnesota Vikings. This game will decide the NFC North and the No. 1 seed in the NFC playoff bracket. Currently, the Lions are three-point favorites with an over-under of 56. 5. Additionally, one playoff spot remains open in each conference. Competing for the AFC spot are the Broncos (-10. 5, 40) and Dolphins (+1. 5, 38. 5), while the Buccaneers and Falcons vie for the NFC South title. When considering which teams to back in these pivotal games, it’s essential to strategize your NFL money line, over-under, and spread picks. Before making any Week 18 NFL picks and predictions, you should consult the NFL against the spread, over-under, and money line predictions provided by SportsLine’s AI. This AI, crafted by SportsLine's Data Science team, uses advanced artificial intelligence and machine learning to evaluate each game. Predictions are generated by analyzing historical data and assessing opposing defenses, resulting in a numeric matchup score out of 100. After establishing a prediction, the AI assigns a rating based on the prediction, matchup score, and market odds. An over bet might receive an A-rating if a team faces a weak defense, the prediction deviates from the line, and the odds are favorable. As SportsLine's first fully automated predictive model, this AI continuously updates using the latest data to help identify line discrepancies.

SportsLine's AI PickBot has achieved 2, 131 4. 5- and 5-star prop picks since last season. For Week 18, the AI PickBot has reviewed the NFL odds and made betting picks for all 16 games, which are exclusively available here. Top Week 18 NFL AI picks: After evaluating all games, the AI PickBot confidently predicts the Buccaneers will cover a 14. 5-point spread against the Saints, with an over-under of 43. 5. The Buccaneers now lead the NFC South after a solid win over the Panthers and the Falcons' loss to the Commanders. Despite 80% of public betting on the Saints to cover, the Buccaneers are favored. Rookie running back Bucky Irving, the first since Doug Martin in 2015 to reach 1, 000 yards for Tampa Bay, alongside Rachaad White, balances their strong passing game. The Buccaneers' offense has exceeded 400 yards in six consecutive games, winning five. In contrast, the Saints struggle with injuries and haven’t scored 20 points or 300 yards lately. They’ve lost their last two outings by 49 points combined and will likely lack players again. This situation explains why the AI PickBot rates a Buccaneers cover as an A-graded pick, predicting an average 30-9 win. Check SportsLine for its other Week 18 predictions. How to make Week 18 NFL picks: The AI PickBot also identified 13 A+ picks for Week 18. You should review these AI PickBot NFL picks at SportsLine before making your bets.