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Molecule AI-gee isku wado ee Insilico Medicine, ISM5939, ayaa helay oggolaanshaha FDA ee IND daawaynta burooyinka adag.
Insilico Medicine, oo ah shirkad ku jirta marxaladda tijaabada caafimaadka oo isticmaaleysa AI-dhalis ah si ay daroogo u ogaadaan, ayaa ku dhawaaqday inay heshay ogolaanshihii FDA IND ee ISM5939. Qalabkan cusub ee afka laga qaato wuxuu xakameynayaa ENPP1 si uu uga hortago burooyinka adag. Tani waa molekuulkii ugu dambeeyay ee Insilico ay si gaar ah u horumarinso oo ruqsad ka hesha tijaabo caafimaad. ENPP1, oo ah ecto-nucleotid pyrophosphatase, waa mid muhiim ah oo saameeya calaamadaha purinergic, una saameeya habka difaaca, wadnaha, neerfaha, iyo dhiigga. Heerarka sare ee ENPP1 waxay la xiriiraan fididda burooyinka iyo natiijooyinka liita. Joojinta ENPP1 waxay kordhisaa saameynta ka hortagga burooyinka ee hab-dhiska difaaca jirka iyadoo la hagaajinayo cGAMP dibedda, hawlgelinaysa habka cGAS-STING. Bishii Meey 2023, Insilico ayaa u aqoonsaday ISM5939 inay tahay musharax preclinical (PCC) ee ENPP1, oo qabta yididiilo ah in loo adeegsado daaweynta kansarka. Xogta preclinical waxay muujinaysaa wax-ku-oolnimada xooggan ee ISM5939 ee meelaha noloshada ah, oo leh astaamo nabadgelyo wanaagsan iyo ku habboonaanta in vitro ADMET iyo pharmacokinetics.
Sujata Rao, M. D. , Madaxa Caafimaadka ee Insilico, ayaa rajadii ka muujiyey natiijooyinka caafimaadka ee ISM5939, isagoo sheegay in amnigeedu fiicanyahay iyo in lagu daro daaweynta kale, taas oo ballaarin karto fursadaha daaweynta kansarka si aad u weyn. Iyadoo ay taageerayso Chemistry42, mashiinka kiimikaad ee Insilico qayb ka ah Pharma. AI, Insilico waxay ku baadhday isku-xir cusub muddo 3 bilood gudahood ah, kadib markii ay hagaajiyeen kiimikistayaashooda caafimaad. Qeybta baarista daroogada ku salaysan AI waxay u baahan tahay natiijooyinka dhabta ah. Insilico waxay xaqiijisay awoodda madalkooda AI iyadoo la gaaray tilmaamo, oo 10 musharax daroogada ah oo gaaray ogolaanshaha IND. Shirkadda waxay u heellan tahay xaqiijinta tubta cilmi-baaristooda gudaheeda iyo horumarka daawada ku shaqeeya AI ee dadka bukaanka ah ee adduunka oo dhan, sida uu sheegay Feng Ren, Ph. D. , Co-CEO iyo Madaxa Cilmi-baarista Sayniska. Sannadkii 2016, Insilico waxay soo bandhigtay isticmaalka AI-dhalis ah ee naqshadeynta mulekul cusub joornaal aqoonyahanimo ah, taas oo saldhig u ahayd madal Pharma. AI. Tan iyo markaas, Insilico waxay ku dhex dhexgalisay horumarka farsamada oo dhan Pharma. AI, waa xal generative AI oo dabooli kara bayoolojiga, kimistariga, horumarinta daawooyinka, iyo baaritaanka sayniska. Iyadoo ay caawiso Pharma. AI, Insilico waxay magacaabtay 20 musharax preclinical waxayna heshay ogolaansho IND loogu talagalay 10 molekul tan iyo 2021. Bishii hore ee 2024, Insilico waxay daabacday maqaalka Nabadda Tiknooloojiyadda oo faahfaahinaya safarka laga bilaabo algorithms AI ilaa tijaabooyinka ka hooseeya marxaladda labaad ee ISM001_055, daawadooda ugu horeysa oo leh bartilmaameedka la ogaaday iyo qaab dhismeedka la naqshadeeyay oo AI ah. Insilico dhawaan waxay soo saartay natiijooyin wanaagsan oo laga helay tijaabada marxaladda labaad (NCT05938920), halkaas oo ISM001_055 ay muujisay amni iyo dulqaad wanaagsan dhammaan heerarka, iyadoo leh jawaab celis ku xiran qiyaasta awoodda neefsashada (FVC) ka dib 12 toddobaad.
Brief news summary
Insilico Medicine ayaa heshay ogolaanshaha FDA IND ee ISM5939, oo ah daawo la naqshadeeyey iyadoo la adeegsanayo AI si loo beegsado enzyme-ka ENPP1 si loo yareeyo burooyinka adag. Tani waa daawadii tobnaad ee AI lagu naqshadeeyo oo ay Insilico gaarsiiso tijaabooyinka caafimaad. ENPP1 waxay la xiriirtaa natiijooyin xun oo kansarka ah, waxaanay ka hortaggeedu kor u qaadi kartaa jawaabta difaaca jidhka ee burooyinka iyada oo loo marayo dariiqa cGAS-STING. ISM5939, oo la bilaabay horumarintiisa bishii Maajo 2023, ayaa muujisay waxtar iyo ammaan xoog leh tijaabooyinka hore. Sujata Rao, Isuduwaha Caafimaadka ee Insilico, ayaa rumeysan in ISM5939 ay kordhin doonto fursadaha daaweynta kansarka. Daawada waxaa la sameeyey iyadoo la adeegsanayo madal Insilico ee Chemistry42, taasoo muujinaysa doorka muhiimka ah ee AI ee qaabeynta daawooyinka. Insilico, oo la aasaasay 2016, waxa ay isticmaashaa AI ee generative ah iyada oo loo marayo madalkeeda Pharma.AI, iyada oo horumarisa 20 musharax oo hore iyo helidda 10 oggolaansho IND tan iyo 2021. Sanadka 2024, Insilico waxay daabacday daraasad muhiim ah oo ku saabsan Nature Biotechnology oo faahfaahinaysa cilmi-baaristooda ku dhiirigelinaysa AI, laga soo bilaabo horumarinta algorithms ilaa tijaabooyinka caafimaad. Waxay sidoo kale soo tebiyeen natiijooyin rajo leh oo ka yimid wajiga labaad ee tijaabada warqadda ah ee daawo kale, ISM001_055, taasoo muujinaysa horumarka ay ka gaareen horumarinta daawooyinka ku dhiirigelinaysa AI.
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