After a commanding victory against the Rams, the Cardinals are set to host the Lions in Week 3, presenting an opportunity to establish themselves as a serious contender in the NFC. Kyler Murray achieved a perfect passer rating last week, and rookie wide receiver showcased his talent by registering four catches for 130 yards and two touchdowns, silencing initial doubts. As three-point underdogs in the latest Week 3 NFL odds, can the Cardinals pull off a win, or will Detroit manage to cover one of the narrowest betting lines of the week?The over/under for this matchup stands at 51. 5, the highest for any game in Week 3. How should you approach this game when making your Week 3 NFL score predictions or placing your bets?Before finalizing any Week 3 NFL selections, it’s essential to consult the NFL predictions against the spread, over/under, and money line, powered by SportsLine AI. Utilizing advanced artificial intelligence and machine learning methods developed by SportsLine's Data Science team, AI Predictions and AI Ratings are formulated for each matchup. These predictions are created by statistically analyzing each team’s historical performance and quantitatively assessing the strength of the opposing defense with a numerical matchup score out of 100. Once a prediction is established, the AI rating is calculated using the prediction, the matchup score, and current market odds. For instance, you might encounter an A-rating on an over bet if a team is up against a weak defense, the prediction diverges from the line, and the odds are favorable. Moreover, SportsLine AI represents the first fully automated predictive model at SportsLine, continuously updating with the latest available data and assisting you in identifying significant line discrepancies. Last season, SportsLine’s AI PickBot achieved an impressive 1, 674 successful 4. 5- and 5-star prop picks, rewarding those who followed it with substantial gains. For Week 3, the AI PickBot has assessed the NFL odds and produced betting predictions for all 16 games.

You can access these AI predictions exclusively for the Week 3 NFL schedule here. **Top Week 3 NFL AI Picks** Following a thorough analysis of every matchup in Week 3, the AI PickBot forecasts that the Rams will cover as 6. 5-point home underdogs against the 49ers. Despite a surprising 10-win season that secured their playoff berth last year, the Rams find themselves with an unanticipated 0-2 start after an overtime defeat to the Lions and a blowout loss to the Cardinals. However, both games were away, and Los Angeles has shown improved performance at home in recent times. The Rams have won five of their last six at SoFi Stadium and are 7-3 against the spread in their last ten games overall. They covered the spread in both encounters against the 49ers last year, including an outright win as 5. 5-point underdogs in Week 18. Both teams face significant absences, with Puka Nacua and Cooper Kupp sidelined for the Rams, and Deebo Samuel and Christian McCaffrey unavailable for the 49ers. Ultimately, the AI PickBot predicts that Los Angeles will stay within the spread this Sunday. For additional Week 3 football predictions and picks, check out SportsLine. **How to Make Week 3 NFL Picks** In addition, the AI PickBot has produced five other A-rated picks for Week 3 that you should consider before finalizing your own bets. You can view these picks exclusively at SportsLine.